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Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking

Two different human diseases, X-linked myotubular myopathy and Charcot-Marie-Tooth disease, result from mutant MTM1 or MTMR2 lipid phosphatases. Although events involved in endosomal PI(3)P and PI(3,5)P(2) synthesis are well established and pivotal in receptor signaling and degradation, enzymes invo...

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Autors principals: Cao, Canhong, Backer, Jonathan M., Laporte, Jocelyn, Bedrick, Edward J., Wandinger-Ness, Angela
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488308/
https://ncbi.nlm.nih.gov/pubmed/18524850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-04-0367
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