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Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

Both caspase-1- and caspase-3-like activities are required for Fas-mediated apoptosis. However, the role of caspase-1 and caspase-3 in mediating Fas-induced cell death is not clear. We assessed the contributions of these caspases to Fas signaling in hepatocyte cell death in vitro. Although wild-type...

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Autors principals: Zheng, Timothy S., Schlosser, Stephan F., Dao, Tao, Hingorani, Ravi, Crispe, I. Nicholas, Boyer, James L., Flavell, Richard A.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24868/
https://ncbi.nlm.nih.gov/pubmed/9811849
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