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Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands
A series of N-substituted-4-cyano-4-phenylpiperidine analogs were synthesized and evaluated for binding affinity at opioid receptors and showed no affinity. The series similarity to previously reported σ ligands prompted analysis at σ receptors to determine the SAR for affinity at σ receptors. Withi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2486414/ https://ncbi.nlm.nih.gov/pubmed/17988766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2007.09.026 |
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