Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

ts1, a spontaneous temperature-sensitive mutant of Moloney murine leukemia virus TB, causes hind-limb paralysis in mice. A Val-25----Ile substitution in gPr80env is responsible for temperature sensitivity, inefficient processing of gPr80env, and neurovirulence. In this study, the Ile-25 in gPr80env...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Szurek, P F, Floyd, E, Yuen, P H, Wong, P K
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248556/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2214016/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.11.5241-5249.1990
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