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DNA Double Strand Breaks Occur Independent of AID in Hypermutating Ig Genes
Somatic hypermutation (SHM) and class switch recombination (CSR) take place in B cells of the germinal center (GC) and are associated with DNA double-strand breaks (DNA-DSBs). Transcription favors the generation of DNA-DSBs in the V-regions and switch regions of Ig genes. Both SHM and CSR are contro...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Hindawi Publishing Corporation
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2485413/ https://ncbi.nlm.nih.gov/pubmed/14768938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10446670310001626571 |
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