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Amino Acids are Necessary for the Insulin-Induced Activation of mTOR/S6K1 Signaling and Protein Synthesis in Healthy and Insulin Resistant Human Skeletal Muscle
BACKGROUND: Amino acids (AA) activate the mammalian target of rapamycin (mTOR) signaling pathway but overactivation has a negative feedback effect on insulin signaling which may lead to insulin resistance and type 2 diabetes (T2DM). Purpose: To determine the effect of reduced AA concentrations on mT...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2484120/ https://ncbi.nlm.nih.gov/pubmed/18342407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clnu.2008.01.012 |
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