Amino Acids are Necessary for the Insulin-Induced Activation of mTOR/S6K1 Signaling and Protein Synthesis in Healthy and Insulin Resistant Human Skeletal Muscle

BACKGROUND: Amino acids (AA) activate the mammalian target of rapamycin (mTOR) signaling pathway but overactivation has a negative feedback effect on insulin signaling which may lead to insulin resistance and type 2 diabetes (T2DM). Purpose: To determine the effect of reduced AA concentrations on mT...

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Hauptverfasser: Drummond, Micah J., Bell, Jill A., Fujita, Satoshi, Dreyer, Hans C., Glynn, Erin L., Volpi, Elena, Rasmussen, Blake B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2484120/
https://ncbi.nlm.nih.gov/pubmed/18342407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clnu.2008.01.012
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