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High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide r...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2483460/ https://ncbi.nlm.nih.gov/pubmed/18598385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2440 |
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