Oncocalyxone A inhibits human platelet aggregation by increasing cGMP and by binding to GP Ibα glycoprotein

BACKGROUND AND PURPOSE: Oncocalyxone A (OncoA) has a concentration-dependent anti-platelet activity. The present study aimed to further understand the mechanisms related to this effect. EXPERIMENTAL APPROACH: Human platelet aggregation was measured by means of a turbidimetric method. OncoA (32–256 μ...

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Detalhes bibliográficos
Main Authors: Ferreira, M A D, do Nascimento, N R F, de Sousa, C M, Pessoa, O D L, de Lemos, T L G, Ventura, J S, Schattner, M, Chudzinski-Tavassi, A M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483390/
https://ncbi.nlm.nih.gov/pubmed/18516074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.199
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