Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53(+/- )mice

INTRODUCTION: Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways conf...

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Bibliographic Details
Main Authors: Dunphy, Karen A, Blackburn, Anneke C, Yan, Haoheng, O'Connell, Lauren R, Jerry, D Joseph
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481490/
https://ncbi.nlm.nih.gov/pubmed/18471300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2094
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