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Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2
CREB is a cAMP- and calcium-responsive transcriptional activator that is required for islet beta cell proliferation and survival. Glucose and incretin hormones elicit beta cell insulin secretion and promote synergistic CREB activity by inducing the nuclear relocalization of TORC2 (also known as Crtc...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481316/ https://ncbi.nlm.nih.gov/pubmed/18626018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800796105 |
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