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Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis
BACKGROUND: Chromatin-associated histone H2AX is a key regulator of the cellular responses to DNA damage. However, non-nucleosomal functions of histone H2AX are poorly characterized. We have recently shown that soluble H2AX can trigger apoptosis but the mechanisms leading to non-chromatin-associated...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481267/ https://ncbi.nlm.nih.gov/pubmed/18616816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-61 |
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