Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis

BACKGROUND: Chromatin-associated histone H2AX is a key regulator of the cellular responses to DNA damage. However, non-nucleosomal functions of histone H2AX are poorly characterized. We have recently shown that soluble H2AX can trigger apoptosis but the mechanisms leading to non-chromatin-associated...

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Bibliographic Details
Main Authors: Liu, Ying, Parry, Joshua A, Chin, Anna, Duensing, Stefan, Duensing, Anette
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481267/
https://ncbi.nlm.nih.gov/pubmed/18616816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-61
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