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Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion
BACKGROUND: Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects. It is a highly lipophilic, poorly soluble drug with oral bioavailab...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481266/ https://ncbi.nlm.nih.gov/pubmed/18613981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-6-8 |
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