Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1

The monoclonal antibody VN04-2 was previously shown to protect mice against lethal A/Vietnam/1203/04 H5N1 virus challenge when administered pre- and post-infection. In this study, we characterized the binding requirements of this antibody using direct binding to hemagglutinin and neutralization assa...

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Hlavní autoři: Lim, Angeline PC, Wong, Steven KK, Chan, Annie HY, Chan, Conrad EZ, Ooi, Eng Eong, Hanson, Brendon J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481255/
https://ncbi.nlm.nih.gov/pubmed/18616831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-5-80
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