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Quantitative Second Harmonic Generation Imaging of the Diseased State Osteogenesis Imperfecta: Experiment and Simulation

We report the integrated use of 3D second harmonic generation (SHG) imaging microscopy and Monte Carlo simulation as a combined metric to quantifiably differentiate normal and diseased tissues based on the physical properties of the respective extracellular matrix. To achieve this, we have identifie...

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Autors principals: LaComb, Ronald, Nadiarnykh, Oleg, Campagnola, Paul J.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480682/
https://ncbi.nlm.nih.gov/pubmed/18281387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.114405
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