Single-Molecule Force Spectroscopy Reveals a Stepwise Unfolding of Caenorhabditis elegans Giant Protein Kinase Domains

Myofibril assembly and disassembly are complex processes that regulate overall muscle mass. Titin kinase has been implicated as an initiating catalyst in signaling pathways that ultimately result in myofibril growth. In titin, the kinase domain is in an ideal position to sense mechanical strain that...

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Autores principales: Greene, Dina N., Garcia, Tzintzuni, Sutton, R. Bryan, Gernert, Kim M., Benian, Guy M., Oberhauser, Andres F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2008
Materias:
Spectroscopy, Imaging, Other Techniques
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2479574/
https://ncbi.nlm.nih.gov/pubmed/18390597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130237
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