Attenuating mutations in glycoproteins E1 and E2 of Sindbis virus produce a highly attenuated strain when combined in vitro.

Alterations in either the E1 or the E2 glycoprotein of Sindbis virus can affect pathogenesis in animals. Previously, we identified two distinct E1 glycoprotein gene sequences which differed in their effect on pathogenesis. One had an attenuation phenotype following subcutaneous inoculation of neonat...

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Pubblicato in:	J Virol
Autori principali:	Polo, J M, Johnston, R E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247913/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.9.4438-4444.1990
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