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Attenuating mutations in glycoproteins E1 and E2 of Sindbis virus produce a highly attenuated strain when combined in vitro.

Alterations in either the E1 or the E2 glycoprotein of Sindbis virus can affect pathogenesis in animals. Previously, we identified two distinct E1 glycoprotein gene sequences which differed in their effect on pathogenesis. One had an attenuation phenotype following subcutaneous inoculation of neonat...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Polo, J M, Johnston, R E
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 1990
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247913/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384921/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.9.4438-4444.1990
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