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Improved Experimental Procedures for Achieving Efficient Germ Line Transmission of Nonobese Diabetic (NOD)-Derived Embryonic Stem Cells

The manipulation of a specific gene in NOD mice, the best animal model for insulin-dependent diabetes mellitus (IDDM), must allow for the precise characterization of the functional involvement of its encoded molecule in the pathogenesis of the disease. Although this has been attempted by the cross-b...

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Detalhes bibliográficos
Main Authors: Arai, Satoko, Minjares, Christina, Nagafuchi, Seiho, Miyazaki, Toru
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2478631/
https://ncbi.nlm.nih.gov/pubmed/15512790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15438600490486877
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