The Type III Secretion Chaperone SycE Promotes a Localized Disorder-to-Order Transition in the Natively Unfolded Effector YopE

Many virulence-related, bacterial effector proteins are translocated directly into the cytosol of host cells by the type III secretion (TTS) system. Translocation of most TTS effectors requires binding by specific chaperones in the bacterial cytosol, although how chaperones promote translocation is...

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Bibliographic Details
Main Authors: Rodgers, Loren, Gamez, Alicia, Riek, Roland, Ghosh, Partho
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475703/
https://ncbi.nlm.nih.gov/pubmed/18502763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802339200
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