Correlation Between Hydrolysis of the β-Lactam Bond of the Cephalosporin Nucleus and Expulsion of the 3-Substituent

The hydrolysis of two cephalosporins by three different β-lactamases has been studied. Each enzyme caused a decrease in ultraviolet absorption, a loss of biological activity, and the release of the leaving group from the 3-position. The changes occurred at the same rate and to the same extent with e...

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Bibliografische Detailangaben

Veröffentlicht in:	J Bacteriol
Hauptverfasser:	O'Callaghan, Cynthia H., Kirby, Susan M., Morris, A., Waller, R. E., Duncombe, R. E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1972
Schlagworte:	Enzymology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247519/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4555421/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.110.3.988-991.1972
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