The interferon-induced protein BST-2/CD317 restricts release of virions from infected cells and is down-regulated from the cell surface by HIV-1 Vpu

The HIV-1 accessory protein Vpu counteracts a cellular factor that restricts the release of virions from infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1.24/CD317 fulfills criteria as this factor. BST-2 is down-regulated from the cell surface by Vpu, and it is expr...

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Bibliographic Details
Main Authors: Van Damme, Nanette, Goff, Daniel, Katsura, Chris, Jorgenson, Rebecca L., Mitchell, Richard, Johnson, Marc, Stephens, Edward B., Guatelli, John
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474773/
https://ncbi.nlm.nih.gov/pubmed/18342597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.03.001
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