Autophagy is an adaptive response in desmin-related cardiomyopathy

A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded proteins. We hypothesized that autophagy increases in response to protein aggregates and that this autophagic activity is adaptive. Mutant C...

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Main Authors: Tannous, Paul, Zhu, Hongxin, Johnstone, Janet L., Shelton, John M., Rajasekaran, Namakkal S., Benjamin, Ivor J., Nguyen, Lan, Gerard, Robert D., Levine, Beth, Rothermel, Beverly A., Hill, Joseph A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474535/
https://ncbi.nlm.nih.gov/pubmed/18621691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706802105
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