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Autophagy is an adaptive response in desmin-related cardiomyopathy
A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded proteins. We hypothesized that autophagy increases in response to protein aggregates and that this autophagic activity is adaptive. Mutant C...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474535/ https://ncbi.nlm.nih.gov/pubmed/18621691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706802105 |
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