Autophagy is an adaptive response in desmin-related cardiomyopathy

A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded proteins. We hypothesized that autophagy increases in response to protein aggregates and that this autophagic activity is adaptive. Mutant C...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Tannous, Paul, Zhu, Hongxin, Johnstone, Janet L., Shelton, John M., Rajasekaran, Namakkal S., Benjamin, Ivor J., Nguyen, Lan, Gerard, Robert D., Levine, Beth, Rothermel, Beverly A., Hill, Joseph A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474535/
https://ncbi.nlm.nih.gov/pubmed/18621691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706802105
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk