Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

Fas activation triggers apoptosis in many cell types. Studies with anti-Fas antibodies have produced conflicting results on Fas signaling, particularly the role of the Bcl-2 family in this process. Comparison between physiological ligand and anti-Fas antibodies revealed that only extensive Fas aggre...

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Hlavní autoři: Huang, David C. S., Hahne, Michael, Schroeter, Michael, Frei, Karl, Fontana, Adriano, Villunger, Andreas, Newton, Kim, Tschopp, Juerg, Strasser, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC24740/
https://ncbi.nlm.nih.gov/pubmed/10611305
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