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Microbial Transformation of Antibiotics: Phosphorylation of Clindamycin by Streptomyces coelicolor Müller

Addition of clindamycin to whole-cell cultures of Streptomyces coelicolor Müller resulted in the loss of in vitro activity against organisms sensitive to clindamycin. Incubation of such culture filtrates with alkaline phosphatase generated a biologically active material identified as clindamycin. Fe...

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Detalles Bibliográficos
Main Authors: Coats, John H., Argoudelis, Alexander D.
Formato: Artigo
Idioma:Inglês
Publicado: 1971
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC247086/
https://ncbi.nlm.nih.gov/pubmed/5166238
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