Mutagenic Action, Loss of Transforming Activity, and Inhibition of Deoxyribonucleic Acid Template Activity In Vitro Caused by Chemical Linkage of Carcinogenic Polycyclic Hydrocarbons to Deoxyribonucleic Acid

In a solvent system of 10(−2)m phosphate buffer (pH 6.8)-ethanol (2:1, v/v) and in an iodine-induced reaction, the polycyclic hydrocarbons [(3)H]3,4-benzpyrene and [(3)H]3,4-BP/[(3)H]9, 10-dimethyl-1,2-benzanthracene (DMBA) can be covalently linked to deoxyribonucleic acid (DNA) at room temperature....

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Bibliografiske detaljer
Main Authors: Maher, Veronica M., Lesko, Stephen A., Straat, Patricia A., Ts'O, Paul O. P.
Format: Artigo
Sprog:Inglês
Udgivet: 1971
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC247052/
https://ncbi.nlm.nih.gov/pubmed/5001197
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