Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in Cpe(fat) mice associated with a carboxypeptidase E mutation
Cpe(fat) mice carry a mutation in the carboxypeptidase E/H gene which encodes an exopeptidase that removes C-terminal basic residues from endoproteolytically cleaved hormone intermediates. These mice have endocrine disorders including obesity, infertility, and hyperproinsulinemia–diabetes syndrome,...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24675/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144234/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5314 |
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