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A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release
An essential step in pre-mRNA splicing is the release of the mRNA product from the spliceosome. The DEAH-box RNA helicase Prp22 catalyzes mRNA release by remodeling contacts within the spliceosome that involve the U5 snRNP. Spliceosome disassembly requires a segment of >13 ribonucleotides downstr...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2465764/ https://ncbi.nlm.nih.gov/pubmed/18570877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.05.003 |
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