Fyn-mediated Phosphorylation of NR2B Tyr-1336 Controls Calpain-mediated NR2B Cleavage in Neurons and Heterologous Systems

Cleavage of the intracellular carboxyl terminus of the N-methyl-D-aspartate (NMDA) receptor 2 subunit (NR2) by calpain regulates NMDA receptor function and localization. Here, we show that Fyn-mediated phosphorylation of NR2B controls calpain-mediated NR2B cleavage. In cultured neurons, calpain-medi...

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Bibliographic Details
Main Authors: Wu, Hai-Yan, Hsu, Fu-Chun, Gleichman, Amy J., Baconguis, Isabelle, Coulter, Douglas A., Lynch, David R.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2464284/
https://ncbi.nlm.nih.gov/pubmed/17526495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700624200
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