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Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone

Steroids produced locally in brain (neurosteroids), including dehydroepiandrosterone (DHEA), influence cognition and behavior. We previously described a novel cytochrome P450, Cyp7b, strongly expressed in rat and mouse brain, particularly in hippocampus. Cyp7b is most similar to steroidogenic P450s...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Rose, Ken A., Stapleton, Genevieve, Dott, Karin, Kieny, Marie Paule, Best, Ruth, Schwarz, Margrit, Russell, David W., Björkhem, Ingemar, Seckl, Jonathan, Lathe, Richard
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144166/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.4925
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