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Microsomal Triglyceride Transfer Protein Enhances Cellular Cholesteryl Esterification by Relieving Product Inhibition

Cholesteryl ester synthesis by the acyl-CoA:cholesterol acyltransferase enzymes ACAT1 and ACAT2 is, in part, a cellular homeostatic mechanism to avoid toxicity associated with high free cholesterol levels. In hepatocytes and enterocytes, cholesteryl esters are secreted as part of apoB lipoproteins,...

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Detalhes bibliográficos
Main Authors: Iqbal, Jahangir, Rudel, Lawrence L., Hussain, M. Mahmood
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459284/
https://ncbi.nlm.nih.gov/pubmed/18502767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800398200
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