Pharmacokinetics of meropenem (ICI 194,660) and its metabolite (ICI 213,689) in healthy subjects and in patients with renal impairment.

The pharmacokinetics of meropenem (ICI 194,660) and its open-ring metabolite (ICI 213,689) were studied in 6 healthy volunteers and 16 patients with moderate to severe renal impairment after a single intravenous dose of 500 mg given as a 30-min infusion. Concentrations of unchanged meropenem in plas...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Leroy, A, Fillastre, J P, Borsa-Lebas, F, Etienne, I, Humbert, G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1482147/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.12.2794
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