Modes of action and inhibitory activities of new siderophore-beta-lactam conjugates that use specific iron uptake pathways for entry into bacteria.

We describe here the mechanism of inhibition of two new siderophore-beta-lactam conjugates against Escherichia coli X580. One conjugate is a spermidine-based catechol siderophore-carbacephalosporin (JAM-2-263), and the other is an N5-acetyl-N5-hydroxy-L-ornithine tripeptide hydroxamate siderophore-c...

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Detalles Bibliográficos
Main Authors: Brochu, A, Brochu, N, Nicas, T I, Parr, T R, Minnick, A A, Dolence, E K, McKee, J A, Miller, M J, Lavoie, M C, Malouin, F
Formato: Artigo
Idioma:Inglês
Publicado: 1992
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC245471/
https://ncbi.nlm.nih.gov/pubmed/1444296
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