Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs.

AIDS dementia complex is a neurologic disorder, characterized by increasingly severe cognitive, behavioral, and motor impairment, which is associated with human immunodeficiency virus (HIV) infection in the central nervous system (CNS). Many of the dideoxynucleosides effective systemically in the tr...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Morgan, M E, Chi, S C, Murakami, K, Mitsuya, H, Anderson, B D
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1444295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.10.2156
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