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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the ανβ3-expressing tumor vasculature. We obs...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2453735/ https://ncbi.nlm.nih.gov/pubmed/18607000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803728105 |
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