A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1(+) smooth muscle progenitor cells

We characterize a sonic hedgehog (Shh) signaling domain restricted to the adventitial layer of artery wall that supports resident Sca1-positive vascular progenitor cells (AdvSca1). Using patched-1 (Ptc1(lacZ)) and patched-2 (Ptc2(lacZ)) reporter mice, adventitial Shh signaling activity was first det...

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Main Authors: Passman, Jenna N., Dong, Xiu Rong, Wu, San-Pin, Maguire, Colin T., Hogan, Kelly A., Bautch, Victoria L., Majesky, Mark W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453724/
https://ncbi.nlm.nih.gov/pubmed/18591670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711382105
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