Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

OBJECTIVE—We have developed a novel platform for display and delivery of bioactive peptides that links the biological properties of the peptide to the pharmacokinetic properties of an antibody. Peptides engineered in the MIMETIBODY platform have improved biochemical and biophysical properties that a...

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Detalhes bibliográficos
Main Authors: Picha, Kristen M., Cunningham, Mark R., Drucker, Daniel J., Mathur, Ashok, Ort, Tatiana, Scully, Michael, Soderman, Avery, Spinka-Doms, Tracy, Stojanovic-Susulic, Vedrana, Ann Thomas, Beth, O'Neil, Karyn T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453616/
https://ncbi.nlm.nih.gov/pubmed/18426860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1775
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