Insulin-like Growth Factor-1 Improves Survival in Sepsis via Enhanced Hepatic Bacterial Clearance

Rationale: Both insulin-like growth factor (IGF)-1 and bacterial clearance by Kupffer cells are significantly reduced in severe sepsis. Kupffer cell apoptosis is triggered by tumor necrosis factor (TNF)-α and activation of the PI-3 kinase pathway prevents TNF-induced Kupffer cell death. Objectives:...

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Detalhes bibliográficos
Main Authors: Ashare, Alix, Nymon, Amanda B., Doerschug, Kevin C., Morrison, John M., Monick, Martha M., Hunninghake, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2008
Assuntos:
D. Critical Care
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453509/
https://ncbi.nlm.nih.gov/pubmed/18436791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200709-1400OC
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