High Protein Binding and Cidal Activity against Penicillin-Resistant S. pneumoniae: A Cefditoren In Vitro Pharmacodynamic Simulation

BACKGROUND: Although protein binding is a reversible phenomenon, it is assumed that antibacterial activity is exclusively exerted by the free (unbound) fraction of antibiotics. METHODOLOGY/PRINCIPAL FINDINGS: Activity of cefditoren, a highly protein bound 3(rd) generation cephalosporin, over 24h aft...

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Bibliographic Details
Main Authors: Sevillano, David, Aguilar, Lorenzo, Alou, Luis, Giménez, María-José, González, Natalia, Torrico, Martha, Cafini, Fabio, Fenoll, Asunción, Coronel, Pilar, Prieto, José
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453320/
https://ncbi.nlm.nih.gov/pubmed/18648650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002717
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