CD4-Specific Designed Ankyrin Repeat Proteins Are Novel Potent HIV Entry Inhibitors with Unique Characteristics

Here, we describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin) technology. DARPin proteins specific for human CD4 were selected from a DARPin DNA library using ribosome display. Selected pool members interacted specifical...

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Detalhes bibliográficos
Main Authors: Schweizer, Andreas, Rusert, Peter, Berlinger, Livia, Ruprecht, Claudia R., Mann, Axel, Corthésy, Stéphanie, Turville, Stuart G., Aravantinou, Meropi, Fischer, Marek, Robbiani, Melissa, Amstutz, Patrick, Trkola, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453315/
https://ncbi.nlm.nih.gov/pubmed/18654624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000109
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