Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys

Although inhibition of dopamine transporters (DAT) and the subsequent increase in dopamine clearly play a role in the effects of psychomotor stimulants, the reinforcing effectiveness of DAT inhibitors varies. Previous studies suggest that pharmacokinetic and pharmacodynamic properties of these drugs...

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Detalhes bibliográficos
Main Authors: Kimmel, Heather L., Negus, S. Stevens, Wilcox, Kristin M., Ewing, Sarah B., Stehouwer, Jeffrey, Goodman, Mark M., Votaw, John R., Mello, Nancy K., Carroll, F. Ivy, Howell, Leonard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453312/
https://ncbi.nlm.nih.gov/pubmed/18468667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.03.032
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