Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory, Toxicologic, and Genome Model Species

BACKGROUND: Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent transcription factor responsible for the regulation of xenobiotic, steroid, and bile acid metabolism. The ligand-binding domain is princip...

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Autors principals: Milnes, Matthew R., Garcia, Adriana, Grossman, Emily, Grün, Felix, Shiotsugu, Jason, Tabb, Michelle M., Kawashima, Yukio, Katsu, Yoshinao, Watanabe, Hajime, Iguchi, Taisen, Blumberg, Bruce
Format: Artigo
Idioma:Inglês
Publicat: National Institute of Environmental Health Sciences 2008
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453155/
https://ncbi.nlm.nih.gov/pubmed/18629309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.10853
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