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Use of Lantibiotic Synthetases for the Preparation of Bioactive Constrained Peptides
Stabilization of biologically active peptides is a major goal in peptide-based drug design. Cyclization is an often-used strategy to enhance resistance of peptides towards protease degradation and simultaneously improve their affinity for targets by restricting their conformational flexibility. Amon...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2452991/ https://ncbi.nlm.nih.gov/pubmed/18294843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.01.062 |
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