Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study

INTRODUCTION: High-mobility group box chromosomal protein 1 (HMGB1) has recently been identified as an endogenous mediator of arthritis. TNF and IL-1β, pivotal cytokines in arthritis pathogenesis, both have the ability to induce the release of HMGB1 from myeloid and dendritic cells. It was, therefor...

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Bibliographische Detailangaben
Hauptverfasser: Sundberg, Erik, Grundtman, Cecilia, af Klint, Erik, Lindberg, Johan, Ernestam, Sofia, Ulfgren, Ann-Kristin, Harris, Helena Erlandsson, Andersson, Ulf
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2452983/
https://ncbi.nlm.nih.gov/pubmed/18346273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2387
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