Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release.

Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in ser...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Urbaschek, R, Männel, D N, Urbanczik, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245238/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929338/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.8.1666
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