Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release.
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in ser...
Kaydedildi:
| Yayımlandı: | Antimicrob Agents Chemother |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology (ASM)
1991
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245238/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929338/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.8.1666 |
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