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Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs.
Pneumocystis carinii was obtained in high yield from the lungs of immunosuppressed rats by rupturing mammalian host cells, washing away the soluble mammalian dihydrofolate reductase, and harvesting intact organisms in association with the mammalian plasma membranes. P. carinii dihydrofolate reductas...
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| Publié dans: | Antimicrob Agents Chemother |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1991
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929292/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.7.1348 |
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