Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.

Cilofungin (LY-121019) is a fungicidal cell wall-active 1,3-beta-glucan synthetase inhibitor with a short plasma half-life and saturable nonlinear plasma pharmacokinetics. To optimize the in vivo efficacy of this compound, we studied the effects of its linear and nonlinear pharmacokinetics during co...

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Detalhes bibliográficos
Main Authors: Walsh, T J, Lee, J W, Kelly, P, Bacher, J, Lecciones, J, Thomas, V, Lyman, C, Coleman, D, Gordee, R, Pizzo, P A
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC245165/
https://ncbi.nlm.nih.gov/pubmed/1929288
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