Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.

Cilofungin (LY-121019) is a fungicidal cell wall-active 1,3-beta-glucan synthetase inhibitor with a short plasma half-life and saturable nonlinear plasma pharmacokinetics. To optimize the in vivo efficacy of this compound, we studied the effects of its linear and nonlinear pharmacokinetics during co...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Walsh, T J, Lee, J W, Kelly, P, Bacher, J, Lecciones, J, Thomas, V, Lyman, C, Coleman, D, Gordee, R, Pizzo, P A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245165/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929288/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.7.1321
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