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Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model

BACKGROUND AND PURPOSE: Bradycardia is a risk factor for the development of torsade de pointes (TdP). The aim of this work was to compare the importance of changes in heart rate and arterial blood pressure in the development of drug-induced TdP and to investigate the role of vagal influences. EXPERI...

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Main Authors: Farkas, A, Dempster, J, Coker, S J
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2451051/
https://ncbi.nlm.nih.gov/pubmed/18587444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.154
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