Regulation of M(2)-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation

BACKGROUND AND PURPOSE: M(2)-type pyruvate kinase (M(2)PK) was found to interact directly with the ‘ITAM' region of the γ chain of the high-affinity IgE receptor (FcɛRI). Our hypothesis was that mast cell degranulation might require the FcɛRI-mediated inhibition of M(2)PK activity. EXPERIMENTAL...

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Detalhes bibliográficos
Main Authors: Ryu, H, Walker, J K L, Kim, S, Koo, N, Barak, L S, Noguchi, T, Kang, B Y, Kim, K-M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2451040/
https://ncbi.nlm.nih.gov/pubmed/18587448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.148
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